What Does A High Kappa Light Chain Mean. A free light chains test measures the amount of lambda and kappa free light chains in the blood. There are two types of light chains:
Also called kappa light chains, they link together with other proteins (heavy chains) to form immunoglobulins (= antibodies) that target and neutralize specific threats to the body (= bacteria & viruses). Light chains come in two basic structures, a lambda chain and a kappa chain. In the context of mgus or myeloma, significantly increased free light chain production and a markedly abnormal kappa/lambda ratio indicate an increased risk of disease progression.